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Poster Session 2, 11:30 AM - 12:15 PM: Campus Center Auditorium [A62]

Presenter: Dylan David Mercier

Faculty Sponsor: Eric Owen Williams

School: Fitchburg State University

Research Area: Biology

ABSTRACT

Dysferlin is a protein in the human body that is essential for rebuilding and repairing muscle tissue. It is encoded by the DYSF gene. If mutations occur in the DYSF gene, however, it can cause the dysferlin protein to become inactive, resulting in a rare form of muscular dystrophy called Dysferlinopathy. This project has two goals, the first one is to identify drugs that can restore dysferlin localization to the plasma membrane of the cell. The other goal of this study is to observe and quantify differentiation in myoblasts with DYSF mutations. We will be using immunostaining, western blotting, and flow cytometry in these experiments to determine our results.

RELATED ABSTRACTS

• Assessing Membrane Repair Capacity in Myoblast Using Dysferlin-Dependent Dye Tagging Techniques, DaPonte, Emma Ashlee, Fitchburg State University, Poster Session 2, 11:30 AM - 12:15 PM, Auditorium, A61
• The Effects of TUDCA on Restoring Dysferlin Protein to the Plasma Membrane in Muscular Dystrophy, Falkenhagen, Alexander, Fitchburg State University, Poster Session 2, 11:30 AM - 12:15 PM, Auditorium, A65
• Investigating the Repressor Sequestration Model of Cilia Length Regulation, Wassouf, Emily Hope, Salem State University, Poster Session 3, 1:15 PM - 2:00 PM, Auditorium, A33