Exploration of α-L-iduronidase (IDUA) Using Virtual Reality Technology

Presenter

Isabella Catao

Group Members

Salam Zaitoun, Erika Mata

Campus

Westfield State University

Sponsor

Roderico Acevedo, Department of Chemical and Physical Sciences, Westfield State University

Schedule

Session 4, 2:30 PM - 3:15 PM [Schedule by Time][Poster Grid for Time/Location]

Location

Poster Board A61, Campus Center Auditorium, Row 4 (A61-A80) [Poster Location Map]

Abstract

Alpha-L-iduronidase (IDUA) is a lysosomal enzyme crucial for the degradation of glycosaminoglycans (GAGs), including heparan sulfate (HS). The breakdown of  GAGs is vital for maintaining proper function. HS production is important as it maintains tissue homeostasis, it interacts with growth factors and acts as a co-receptor in signaling pathways being involved in cell signaling regulation, cell adhesion, cellular clearance, anticoagulant properties, and extracellular matrix structure it supports normal development and function in the body. Understanding how IDUA interacts with HS at the atomic level could lead to the development of novel treatments for lysosomal storage disorders such as mucopolysaccharidosis type I (MPS I). Here, we will show how IDUA cleaves GAGs to produce HS, using the virtual reality application, Nanome. This 3D software offers us a unique view at traditionally viewed 2D mechanisms, by allowing us to easily measure the distances between atoms directly in 3D space using our hands while inside an enzyme’s active site. Using virtual reality technology in the classroom could help future students gain a deeper understanding of the critical chemical reactions that occur in biological systems.

Keywords

Virtual Reality, Enzyme Catalysis , Reaction Mechanisms

Research Area

Chemistry and Materials Science

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