A Scoping Review of Tuberculosis Burden among Young People With Diabetes In Low- and Middle-Income Countries

Presenter

Natalie Anne Wessell

Group Members

Sara Hershberg, Lisa Nguyen

Campus

UMass Amherst

Sponsor

Krishna Poudel, Department of Health Promotion and Policy, UMass Amherst

Schedule

Session 4, 2:30 PM - 3:15 PM [Schedule by Time][Poster Grid for Time/Location]

Location

Poster Board C34, Poster Showcase Room (163), Row 4 (C31-C40) [Poster Location Map]

Abstract

Natalie Wessell, Sara Hershberg, Lisa Nguyen

BACKGROUND

It is important to be aware of the connection between Type 1 diabetes mellitus (T1DM) in children and their risk of becoming ill with tuberculosis (TB) or having latent TB. We reviewed published literature on the prevalence of TB in adolescents and youth (ages 10-25) with T1DM.

METHODS

We searched studies in PubMed, UMass Amherst Library Database, Google Scholar, Oxford Academic, and reviewed ones published from July 2009 to April 2022. Each study focuses on the relationship between TB (including latent TB) and T1DM in individuals of 10-25 years in low- and middle-income countries.

RESULTS

Ten publications met the inclusion criteria: six cross-sectional and four cohort studies. Studies reported TB prevalence ranging from 26% to 76% among adolescents and youth. Individuals with T1DM were more likely (4.07-6.8 fold) to develop TB in the future. All studies presented TB status to be associated with a range of risk factors, including HbA1c (glucose), duration of diabetes, glycemic control, contact with a TB source, childhood obesity, smoking, sedentary lifestyle, HIV infection, socioeconomic status, and health care access.

CONCLUSION

Our review revealed that adolescents and youth with diabetes mellitus have a significantly higher chance of developing TB than those without diabetes mellitus. Our findings suggest the need to develop specific health policies, strategies, techniques, or technologies to identify risk factors early and lessen the disease burden among adolescents and youth in low- and middle-income countries.

Keywords

Youth, Diabetes, Tuberculosis, Infection, Low- and Middle Income Countries

Research Area

Public Health and Epidemiology

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