Curcumin is a naturally occurring bioactive molecule that belongs to the class of molecules called curcuminoids. It is extracted from the rhizome of Curcuma longa and is most notably found in turmeric, being the primary pigment for its bright orange color. The compound has been researched extensively due to its antioxidant, anti-inflammatory, antimicrobial, anticancer and wound healing properties as well as its potential therapeutic applications in diseases such as Alzheimer’s Disease (AD). Curcumin has been shown to bind to amyloid-beta plaques, which are a hypothesized cause of AD, and has been shown to be a promising treatment and diagnostic probe. However, curcumin is not water soluble and has very low bioavailability in the human body. Solid lipid nanoparticles (SLNs) provide a viable approach by using their hydrophobic properties to protect and separate the encapsulated drug from the surrounding aqueous environment. Their solubility and effectiveness depend on their specific formulation. Our research investigates SLN formulations for increased solubility and emulsification of curcumin in aqueous solutions. A procedure was developed to test SLN stability in simulated gastric acid. Curcumin concentrations over time were determined using UV/Vis spectroscopy based on a standard curve. The most stable formulation was further investigated and characterized using fluorescence microscopy and Infrared (IR) spectroscopy.