Synthesis and Reactions of Iron(III) mu-oxo-bridged Tetraphenylporphyrin

Presenter

Zachary J. Desir

Campus

Fitchburg State University

Sponsor

Dennis Awasabisah, Department of Biology and Chemistry, Fitchburg State University

Schedule

Session 5, 3:30 PM - 4:15 PM [Schedule by Time][Poster Grid for Time/Location]

Location

Poster Board C3, Poster Showcase Room (163), Row 1 (C1-C10) [Poster Location Map]

Abstract

Globally, the WHO reported almost 250 million cases of malaria in 2022, highlighting the pervasive impact of this illness worldwide. Sadly, this is an increase of 5 million cases compared to 2021, with four African countries accounting for almost half of all cases. Efforts to combat malaria necessitate the development of anti-malarial drugs that not only effectively treat infections, but also offer long-term solutions. Within the pharmaceutical sector, there is a call for more sustainable drug options that target heme and prevent hemozoin formation. My focus is on identifying a drug that precisely targets heme in its mechanism of action. In our research, we use synthetic heme models to understand the heme or hemozoin-drug interactions. To this end, we have synthesized Iron(III) mu-oxo-bridged tetraphenylporphyrin as synthetic models of hemozoin and have studied their reactions with chemical moieties found in antimalarials.We present IR, NMR and UV-vis spectroscopic data of the compounds. Data from this work provides more insight on the role of antimalarials in inhibiting hemozoin formation. 

Keywords

Malaria, Anti-Malarial Drugs, Hemozoin Models

Research Area

Chemistry and Materials Science

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